Dysautonomia, associated with autonomic nervous system dysfunction, can manifest in various ways, including chronic fatigue, cognitive problems, cardiovascular dysfunction, e.g. low blood pressure, elevated heart rate, and mental health disorders. Lack of Thiamine (Vitamin B1), as one possibility of dysautonomia, can compromise mitochondrial function leading to imbalanced activity within the autonomic nervous system (ANS). There are other considerations too such as Dopamine Beta-Hydroxylase deficiency. This lecture will focus on certain aspects of dysautonomia.